GSK 356278 ( GSK356278;GSK-356278 )

产品货号. M15757 CAS No. 720704-34-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

GSK 356278
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B); equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7.
产品描述

A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B); equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7, exhibits >100-fold selectivity for PDE4B over the other 10 PDEs; inhibits LPS-induced release of TNF-α in human whole blood with pIC50 of 7.6, demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in models of anxiety.Anxiety Phase 1 Clinical
同义词

GSK356278;GSK-356278
通路

Angiogenesis
靶点

PDE
受体

PDE
研究领域

Neurological Disease
适应症

Anxiety

CAS Number

720704-34-7
分子量

439.54
分子式

C21H25N7O2S
纯度

>98% (HPLC)
溶解度

——
SMILES

CCN1N=CC2=C(NC3CCOCC3)C(C4=NN=C(CC5=C(C)N=C(C)S5)O4)=CN=C21
化学全称

5-(5-((2,4-dimethylthiazol-5-yl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

1. Rutter AR, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63.
2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.

计算器

产品手册

关联产品

BI-409306

BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.
Ginkgolide J

Ginkgolide J has neuroprotective activity it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.
PF-2545920

PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM.